The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core.

Journal article

SYCP3 localizes to the lateral elements of the synaptonemal complex and is essential for male meiosis. The genomic structure of SYCP3 consists of nine exons spanning approximately 14 kb. In mouse and rat, but not in hamster, the putative translation start of SYCP3 is present in the first exon. The putative promoter of SYCP3 was also cloned and shown to drive transcription of a reporter gene in somatic cells.

Authors: Botelho, R; DiNicolo, L; Tsao, N; Karaiskakis, A; Tarsounas, M

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1518
• Issue: 3
• Pages: 294-299
• Publication date: 2001-04-01
• DOI: 10.1016/s0167-4781(01)00171-3
• ISSN: 0006-3002
• Language: English
• Keywords: Synaptonemal Complex; Animals; 3T3 Cells; Transfection; Introns; Nuclear Proteins; Amino Acid Sequence; Molecular Sequence Data; Mice; Meiosis; Promoter Regions, Genetic; Base Sequence; Exons