Mechanisms of coronary microvascular adaptation to obesity.

Journal article

Abstract:: The metabolic syndrome (MetS) is associated with clustering of cardiovascular risk factors in individuals that may greatly increase their risk of developing coronary artery disease. Obesity and related metabolic dysfunction are the driving forces in the prevalence of MetS. It is believed that obesity has detrimental effects on cardiovascular function, but its overall impact on the vasomotor regulation of small coronary arteries is still debated. Emerging evidence indicates that in obesity cor...
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Institution:

University of Oxford

Division:

MSD

Department:

Pharmacology

Role:

Author

Journal:: American journal of physiology. Regulatory, integrative and comparative physiology More from this journal
Volume:: 297
Issue:: 3
Pages:: R556-R567
Publication date:: 2009-09-01
DOI:: 10.1152/ajpregu.90817.2008
EISSN:: 1522-1490
ISSN:: 0363-6119

Language:: English
Keywords:: Signal Transduction

Adaptation, Physiological

Coronary Circulation

Vasodilation

Microcirculation

Muscle, Smooth, Vascular

Animals

Metabolic Syndrome X

Obesity

Coronary Vessels

Cardiovascular Diseases

Humans

Endothelium, Vascular
Pubs id:: pubs:164435
UUID:: uuid:ff6ec2dd-3aa1-47f5-844b-fb40e1fa3611
Local pid:: pubs:164435
Source identifiers:: 164435
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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