Journal article
Pentamethylphenyl (Ph*) ketones: Unique building blocks for organic synthesis
- Abstract:
- Pentamethylphenyl (Ph*) ketones are rapidly emerging as versatile and useful building blocks for organic synthesis. The ortho-methyl substituents force the aromatic ring to twist out of planarity with the carbonyl, and consequently these molecules display a unique pattern of reactivity which is completely distinct to that of traditional aromatic ketones. The primary aim of this Digest is to highlight examples where new chemical reactivity is unlocked through the use of Ph* ketones, and a wide range of examples are presented including hydrogen borrowing catalysis, aldol addition and organocatalysis. Finally, methods to cleave the Ph* group to a range of other functionality are surveyed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tetlet.2021.153151
Authors
- Publisher:
- Elsevier
- Journal:
- Tetrahedron Letters More from this journal
- Volume:
- 74
- Article number:
- 153151
- Publication date:
- 2021-05-05
- Acceptance date:
- 2021-05-01
- DOI:
- ISSN:
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0040-4039
- Language:
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English
- Keywords:
- Pubs id:
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1174043
- Local pid:
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pubs:1174043
- Deposit date:
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2021-05-04
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Elsevier Ltd. All rights reserved.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from Elsevier at https://doi.org/10.1016/j.tetlet.2021.153151
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