Journal article
Antibacterial mimics of natural products by side-chain functionalization of bicyclic tetramic acids
- Abstract:
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Tetramic acids with unsaturated acyl chains are widely found in natural products possessing a range of biological activities, and bicyclic tetramates represent a suitable scaffold to prepare simple mimics of such complex molecules. An efficient route to functionalize the C(6)-acyl group of a bicyclic tetramate was developed and utilized to prepare a small chemical library with a range of saturated and unsaturated side-chains. The analogues with lipophilic residues possessed highly potent anti...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 718.4KB, Terms of use)
-
- Publisher copy:
- 10.1021/acs.joc.8b01453
Authors
Funding
+ European Union
More from this funder
Funding agency for:
Josa-Cullere, L
Grant:
People Programme (Marie
Curie Actions) 316955
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 83
- Issue:
- 17
- Pages:
- 10303–10317
- Publication date:
- 2018-07-20
- Acceptance date:
- 2018-07-20
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
- Pmid:
-
30028145
Item Description
- Language:
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English
- Pubs id:
-
pubs:891119
- UUID:
-
uuid:ff337d61-f9a6-4d23-be9c-ef659cdf65f0
- Local pid:
-
pubs:891119
- Source identifiers:
-
891119
- Deposit date:
-
2018-08-10
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.joc.8b01453
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