The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.

Journal article

The PB2 subunit of the influenza virus RNA polymerase is a major virulence determinant of influenza viruses. However, the molecular mechanisms involved remain unknown. It was previously shown that the PB2 protein, in addition to its nuclear localization, also accumulates in the mitochondria. Here, we demonstrate that the PB2 protein interacts with the mitochondrial antiviral signaling protein, MAVS (also known as IPS-1, VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-beta) e...

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Authors: Graef, K; Vreede, F; Lau, Y; McCall, A; Carr, S

• Publication status: Published
• Journal: Journal of virology
• Volume: 84
• Issue: 17
• Pages: 8433-8445
• Publication date: 2010-09-01
• DOI: 10.1128/jvi.00879-10
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Host-Pathogen Interactions; Amino Acid Sequence; Influenza A Virus, H1N1 Subtype; Humans; Molecular Sequence Data; Influenza, Human; Down-Regulation; Virulence; Animals; Viral Proteins; Female; Mice, Inbred C57BL; Protein Binding; Influenza A Virus, H2N2 Subtype; Adaptor Proteins, Signal Transducing; Sequence Alignment; Interferon-beta; Mice; Influenza A virus; Influenza A Virus, H5N1 Subtype; RNA Replicase