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Journal article

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy.

Abstract:

During chronic HIV-1 infection, continuing viral replication is associated with impaired proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence of oligoclonal T cell populations. TCR usage may significantly influence CD8+ T cell-mediated control of AIDS viruses; however, the potential to modulate the repertoire of functional virus-specific T cells by immunotherapy has not been explored. To investigate this, we analyzed the TCR Vbeta usage of CD8+ T cells ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.179.1.597

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Turnbull, E More by this author
Ranasinghe, S More by this author
Ondondo, B More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
179
Issue:
1
Pages:
597-606
Publication date:
2007-07-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:ff0f57d2-5e22-43db-9195-475006170ef1
Source identifiers:
30037
Local pid:
pubs:30037

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