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Journal article

Cloning in action: can embryo splitting, induced pluripotency and somatic cell nuclear transfer contribute to endangered species conservation?

Abstract:
The term 'cloning' refers to the production of genetically identical individuals but has meant different things throughout the history of science: a natural means of reproduction in bacteria, a routine procedure in horticulture, and an ever-evolving gamut of molecular technologies in vertebrates. Mammalian cloning can be achieved through embryo splitting, somatic cell nuclear transfer, and most recently, by the use of induced pluripotent stem cells. Several emerging biotechnologies also facilitate the propagation of genomes from one generation to the next whilst bypassing the conventional reproductive processes. In this review, we examine the state of the art of available cloning technologies and their progress in species other than humans and rodent models, in order to provide a critical overview of their readiness and relevance for application in endangered animal conservation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/brv.12951

Authors


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Role:
Author
ORCID:
0000-0001-7371-5400
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Role:
Author
ORCID:
0000-0002-0170-1963
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Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Role:
Author
ORCID:
0000-0003-1798-976X


Publisher:
Wiley
Journal:
Biological Reviews More from this journal
Volume:
98
Issue:
4
Pages:
1225-1249
Place of publication:
England
Publication date:
2023-04-04
Acceptance date:
2023-03-13
DOI:
EISSN:
1469-185X
ISSN:
1464-7931
Pmid:
37016502


Language:
English
Keywords:
Pubs id:
1338117
Local pid:
pubs:1338117
Deposit date:
2023-05-25

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