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PLCζ and its role as a trigger of development in vertebrates.

Abstract:

A major unresolved issue in developmental biology is the precise mechanism whereby the sperm activates the oocyte. With the discovery that calcium signals are the primary trigger for oocyte activation, a key remaining question became the identification of the signaling protein that mediates such calcium signals at fertilization. A major step forward came in 2002 with the discovery of a sperm-specific mammalian phospholipase C called phospholipase C zeta (PLCζ), which had the expected properti...

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Publication status:
Published

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Publisher copy:
10.1002/mrd.21359

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Fissore, RA More by this author
Journal:
Molecular reproduction and development
Volume:
78
Issue:
10-11
Pages:
846-853
Publication date:
2011
DOI:
EISSN:
1098-2795
ISSN:
1040-452X
URN:
uuid:fedd7026-4677-466b-9937-7d5c5a19d0e4
Source identifiers:
185383
Local pid:
pubs:185383

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