Journal article
A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer.
- Abstract:
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PURPOSE: To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. METHODS: Chemical modifications of genistein have been introduced to improve its solubility and efficacy. The anti-tumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle analysis, immunofluorescence, and microscopy. RESULTS: In this work, we show that a unique glycoside of genistein, ITB-301, inhibits the proliferation of SKOv3 ovarian cancer cells. We found that t...
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- Publisher copy:
- 10.1007/s00280-011-1575-2
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Bibliographic Details
- Journal:
- Cancer chemotherapy and pharmacology
- Volume:
- 68
- Issue:
- 4
- Pages:
- 1033-1044
- Publication date:
- 2011-10-01
- DOI:
- EISSN:
-
1432-0843
- ISSN:
-
0344-5704
- Source identifiers:
-
248405
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:248405
- UUID:
-
uuid:fed6e770-012d-4468-adcd-6e18dcb9d22a
- Local pid:
- pubs:248405
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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