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A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer.

Abstract:

PURPOSE: To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. METHODS: Chemical modifications of genistein have been introduced to improve its solubility and efficacy. The anti-tumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle analysis, immunofluorescence, and microscopy. RESULTS: In this work, we show that a unique glycoside of genistein, ITB-301, inhibits the proliferation of SKOv3 ovarian cancer cells. We found that t...

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Publisher copy:
10.1007/s00280-011-1575-2

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Journal:
Cancer chemotherapy and pharmacology
Volume:
68
Issue:
4
Pages:
1033-1044
Publication date:
2011-10-01
DOI:
EISSN:
1432-0843
ISSN:
0344-5704
Source identifiers:
248405

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