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Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ signals.

Abstract:

In addition to its well established function in activating Ca(2+) release from the endoplasmic reticulum (ER) through ryanodine receptors (RyR), the second messenger cyclic ADP-ribose (cADPR) also accelerates the activity of SERCA pumps, which sequester Ca(2+) into the ER. Here, we demonstrate a potential physiological role for cADPR in modulating cellular Ca(2+) signals via changes in ER Ca(2+) store content, by imaging Ca(2+) liberation through inositol trisphosphate receptors (IP(3)R) in X...

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Publisher copy:
10.1074/jbc.m109.095257

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
285
Issue:
32
Pages:
25053-25061
Publication date:
2010-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:feca4865-10ed-42a3-a08c-29ac6076aca3
Source identifiers:
258442
Local pid:
pubs:258442

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