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Meaningful improvement in general health outcomes with Guselkumab treatment for psoriatic arthritis: Patient-Reported Outcomes Measurement Information System-29 results from a phase 3 study

Abstract:
Objective The Phase 3 DISCOVER-1 study of guselkumab is the first randomized controlled trial to use Patient-Reported Outcomes Measurement Information System (PROMIS) measures to assess the effects of treatment on general health outcomes in patients with psoriatic arthritis (PsA).
Methods Patients (N = 381) with active PsA were randomized 1:1:1 to guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at Week 0, Week 4, then every 8 weeks (Q8W); or pla... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s40271-022-00588-6

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Role:
Author
ORCID:
0000-0001-8644-8567
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0002-4756-663X
Publisher:
Springer
Journal:
Patient -- Patient-Centered Outcomes Research More from this journal
Volume:
15
Issue:
6
Pages:
657–668
Publication date:
2022-06-30
Acceptance date:
2022-05-19
DOI:
EISSN:
1178-1661
ISSN:
1178-1653
Pmid:
35768650
Language:
English
Keywords:
Pubs id:
1266857
Local pid:
pubs:1266857
Deposit date:
2022-07-20

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