Journal article icon

Journal article

Genome-wide epistasis and co-selection study using mutual information

Abstract:

Covariance-based discovery of polymorphisms under co-selective pressure or epistasis has received considerable recent attention in population genomics. Both statistical modeling of the population level covariation of alleles across the chromosome and model-free testing of dependencies between pairs of polymorphisms have been shown to successfully uncover patterns of selection in bacterial populations. Here we introduce a model-free method, SpydrPick, whose computational efficiency enables ana...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Role:
Author
ORCID:
0000-0002-5158-5761
More from this funder
Name:
Wellcome Trust
Grant:
098051
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
47
Issue:
18
Article number:
e112
Publication date:
2019-07-30
Acceptance date:
2019-07-19
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
31361894
Language:
English
Keywords:
Subjects:
Pubs id:
1037920
Local pid:
pubs:1037920
Deposit date:
2020-04-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP