The new immunosuppression: intervention at the dendritic cell-T-cell interface.

Journal article

Abstract:: Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.

Journal:: Current drug targets. Immune, endocrine and metabolic disorders More from this journal
Volume:: 5
Issue:: 4
Pages:: 397-411
Publication date:: 2005-12-01
DOI:: 10.2174/156800805774912935
EISSN:: 0000-0000
ISSN:: 1568-0088

Language:: English
Keywords:: T-Lymphocytes

Humans

Antibodies, Monoclonal

Immunosuppression

Immune Tolerance

Graft Rejection

Animals

Dendritic Cells

Immunosuppressive Agents
Pubs id:: pubs:15170
UUID:: uuid:feaa67c8-2ef3-4d4c-bf11-5a7c7918e92f
Local pid:: pubs:15170
Source identifiers:: 15170
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_feaa67c82ef34d4cbf115a7c7918e92f

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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