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Hypoxia induces a lipogenic cancer cell phenotype via HIF1a-dependent and -independent pathways

Abstract:

The biochemistry of cancer cells diverges significantly from normal cells as a result of a comprehensive reprogramming of metabolic pathways. A major factor influencing cancer metabolism is hypoxia, which is mediated by HIF1a and HIF2a. HIF1a represents one of the principal regulators of metabolism and energetic balance in cancer cells through its regulation of glycolysis, glycogen synthesis, Krebs cycle and the pentose phosphate shunt. However, less is known about the role of HIF1a in modula...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.18632/oncotarget.3058

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
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Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
6
Issue:
4
Pages:
1920-1941
Chapter number:
0
Publication date:
2014-12-11
Acceptance date:
2014-12-10
DOI:
EISSN:
1949-2553
ISSN:
1949-2553
URN:
uuid:fe9b1090-a1ff-443a-ab22-670988cc61bf
Source identifiers:
503911
Local pid:
pubs:503911
Paper number:
4

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