- Abstract:
-
The biochemistry of cancer cells diverges significantly from normal cells as a result of a comprehensive reprogramming of metabolic pathways. A major factor influencing cancer metabolism is hypoxia, which is mediated by HIF1a and HIF2a. HIF1a represents one of the principal regulators of metabolism and energetic balance in cancer cells through its regulation of glycolysis, glycogen synthesis, Krebs cycle and the pentose phosphate shunt. However, less is known about the role of HIF1a in modula...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 6.1MB)
-
- Publisher copy:
- 10.18632/oncotarget.3058
-
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- Publisher:
- Impact Journals Publisher's website
- Journal:
- Oncotarget Journal website
- Volume:
- 6
- Issue:
- 4
- Pages:
- 1920-1941
- Chapter number:
- 0
- Publication date:
- 2014-12-11
- Acceptance date:
- 2014-12-10
- DOI:
- EISSN:
-
1949-2553
- ISSN:
-
1949-2553
- URN:
-
uuid:fe9b1090-a1ff-443a-ab22-670988cc61bf
- Source identifiers:
-
503911
- Local pid:
- pubs:503911
- Paper number:
- 4
- Language:
- English
- Keywords:
- Copyright holder:
- Alessandro Valli et al
- Copyright date:
- 2014
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 License (http://creativecommons.org/licenses/by/3.0/).
Journal article
Hypoxia induces a lipogenic cancer cell phenotype via HIF1a-dependent and -independent pathways
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