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Significance of DNA polymerase I in in vivo processing of clustered DNA damage.

Abstract:

We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay. Following transformation with the plasmid containing bi-stranded clustered damage sites into the wild type strain of Escherichia coli, transformation frequencies were significantly lower for the bi-stranded clustered GAP/AP...

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Publication status:
Published

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Journal:
Mutation research More from this journal
Volume:
749
Issue:
1-2
Pages:
9-15
Publication date:
2013-09-01
DOI:
EISSN:
1873-135X
ISSN:
0027-5107
Language:
English
Keywords:
Pubs id:
pubs:426382
UUID:
uuid:fe8fb1b2-a45a-419d-a4d3-655a9a7851e3
Local pid:
pubs:426382
Source identifiers:
426382
Deposit date:
2013-12-11

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