Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices

Journal article

Background: Routine echocardiographic monitoring is recommended in muscular dystrophy patients to detect left ventricular systolic dysfunction (LVSD) but is often challenging due to physical limitations. This study evaluates whether artificial intelligence-based electrocardiogram interpretation (AI-ECG) can detect and predict LVSD in muscular dystrophy patients. Methods: Patients aged >16 years who underwent an ECG and echocardiogram within 90 days at the University Medical Center Utrecht were included. Patients with Duchenne (DMD), Becker (BMD), limb-girdle muscular dystrophy (LGMD). myotonic dystrophy (MD), and female DMD/BMD carriers, were identified. A convolutional neural network (CNN) was trained on a derivation cohort of patients without muscular dystrophy to detect LVSD and tested on muscular dystrophy patients. A Cox proportional hazards model assessed AI-ECG's predictive value for new-onset LVSD. Results: The derivation cohort included 53,874 ECG-echocardiogram pairs from 30,978 patients, while the muscular dystrophy test set comprised 390 ECG-echo pairs from 390 patients. LVSD prevalence varied from 81.3 % in DMD to 13.4 % in MD. The model achieved an AUROC of 0.83 (0.79–0.87) in the muscular dystrophy test set, with sensitivity 0.87 (0.81–0.93), specificity 0.58 (0.52–0.63), NPV 0.91 (0.86–0.95), and PPV 0.49 (0.43–0.56). AI-ECG predicted new-onset LVSD with an AUROC of 0.72 (0.66–0.78), with AI-ECG probability being a significant predictor. Conclusions: AI-ECG can detect LVSD in muscular dystrophy patients, offering a non-invasive, accessible tool for risk stratification and an alternative to routine echocardiography. It may also predict new-onset LVSD, enabling earlier intervention. Further research should explore external validation, pediatric application, and integration within the clinical care plan.

Authors: Khunte, A; Sangha, V; Oikonomou, EK; Dhingra, LS; Aminorroaya, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: npj Digital Medicine
• Volume: 6
• Issue: 1
• Pages: 124-124
• Article number: 124
• Publication date: 2023-07-11
• DOI: 10.1038/s41746-023-00869-w
• EISSN: 2398-6352
• ISSN: 2398-6352
• Language: English
• Keywords: Electrocardiography; Pattern recognition (psychology); Medicine; Computer science; Cardiology; Wearable computer; Noise (video); Artificial intelligence; Embedded system; Gaussian noise; Wearable technology