- Abstract:
-
Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.We used individual patient data from the Stroke Thrombolysis Trialists' (STT) meta-analysis of randomised...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 1.1MB)
-
- Publisher copy:
- 10.1016/S1474-4422(16)30076-X
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Lancet Neurology Journal website
- Volume:
- 15
- Issue:
- 9
- Pages:
- 925-933
- Publication date:
- 2016-08-05
- DOI:
- EISSN:
-
1474-4465
- ISSN:
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1474-4422
- Pubs id:
-
pubs:628353
- URN:
-
uri:fe283959-73dc-423e-9764-aba582065630
- UUID:
-
uuid:fe283959-73dc-423e-9764-aba582065630
- Local pid:
- pubs:628353
- Paper number:
- 9
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Elsevier Ltd.
Journal article
Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis
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Authors
Funding
Medical Research Council
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British Heart Foundation
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University of Glasgow
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University of Edinburgh
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