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Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

Abstract:

Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.We used individual patient data from the Stroke Thrombolysis Trialists' (STT) meta-analysis of randomised...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Publisher:
Elsevier
Journal:
Lancet Neurology More from this journal
Volume:
15
Issue:
9
Pages:
925-933
Publication date:
2016-08-01
Acceptance date:
2016-05-04
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
Pmid:
27289487
Language:
English
Keywords:
Pubs id:
pubs:628353
UUID:
uuid:fe283959-73dc-423e-9764-aba582065630
Local pid:
pubs:628353
Source identifiers:
628353
Deposit date:
2016-11-03

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