Journal article

Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

Abstract:: Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.We used individual patient data from the Stroke Thrombolysis Trialists' (STT) meta-analysis of randomised...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Whiteley, W., Emberson, J., Lees, K., Blackwell, L., Albers, G., Bluhmki, E., Brott, T., Cohen, G., Davis, S., Donnan, G., Grotta, J., Howard, G., Kaste, M., Koga, M., von Kummer, R., Lansberg, M., Lindley, R., Lyden, P., Olivot, J., … Baigent, C. (2016). Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurology, 15(9), 925–933.

MLA Style

Whiteley, W., et al. “Risk of Intracerebral Haemorrhage with Alteplase after Acute Ischaemic Stroke: a Secondary Analysis of an Individual Patient Data Meta-Analysis.” Lancet Neurology, vol. 15, no. 9, Elsevier, 2016, pp. 925–33.

Chicago Style

Whiteley, W, J Emberson, K Lees, L Blackwell, G Albers, E Bluhmki, T Brott, et al. 2016. “Risk of Intracerebral Haemorrhage with Alteplase after Acute Ischaemic Stroke: a Secondary Analysis of an Individual Patient Data Meta-Analysis.” Lancet Neurology 15 (9): 925–33.
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Files:: Emberson et al, Risk of intracerebral haemorrhage with altepla...

(Preview, Accepted manuscript, pdf, 1.1MB, Terms of use)

Publisher copy:: 10.1016/S1474-4422(16)30076-X

Authors

+ Whiteley, W More by this author

Role:: Author

+ Emberson, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

+ Lees, K More by this author

Role:: Author

+ Blackwell, L More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

+ Albers, G More by this author

Role:: Author

More authors...

+ University of Edinburgh More from this funder

+ University of Glasgow More from this funder

+ British Heart Foundation More from this funder

+ Medical Research Council More from this funder

Publisher:: Elsevier
Journal:: Lancet Neurology More from this journal
Volume:: 15
Issue:: 9
Pages:: 925-933
Publication date:: 2016-08-01
Acceptance date:: 2016-05-04
DOI:: 10.1016/S1474-4422(16)30076-X
EISSN:: 1474-4465
ISSN:: 1474-4422
Pmid:: 27289487

Language:: English
Keywords:: Stroke Thrombolysis Trialists' Collaboration
Pubs id:: pubs:628353
UUID:: uuid:fe283959-73dc-423e-9764-aba582065630
Local pid:: pubs:628353
Source identifiers:: 628353
Deposit date:: 2016-11-03

Terms of use

Copyright holder:: Elsevier Ltd
Copyright date:: 2016
Notes:: Copyright © 2016 Elsevier Ltd.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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