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Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

Abstract:

Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.We used individual patient data from the Stroke Thrombolysis Trialists' (STT) meta-analysis of randomised...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/S1474-4422(16)30076-X

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Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
More by this author
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Medical Research Council More from this funder
British Heart Foundation More from this funder
University of Glasgow More from this funder
University of Edinburgh More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Neurology Journal website
Volume:
15
Issue:
9
Pages:
925-933
Publication date:
2016-08-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
Pubs id:
pubs:628353
URN:
uri:fe283959-73dc-423e-9764-aba582065630
UUID:
uuid:fe283959-73dc-423e-9764-aba582065630
Local pid:
pubs:628353
Paper number:
9
Language:
English
Keywords:

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