AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale

Journal article

Over the past decade, the intricacies of sports-related concussions among female athletes have become readily apparent. Traditional clinical methods for diagnosing concussions suffer limitations when applied to female athletes, often failing to capture subtle changes in brain structure and function. Advanced neuroinformatics techniques and machine learning models have become invaluable assets in this endeavor. While these technologies have been extensively employed in understanding concussion in male athletes, there remains a significant gap in our comprehension of their effectiveness for female athletes. With its remarkable data analysis capacity, machine learning offers a promising avenue to bridge this deficit. By harnessing the power of machine learning, researchers can link observed phenotypic neuroimaging data to sex-specific biological mechanisms, unraveling the mysteries of concussions in female athletes. Furthermore, embedding methods within machine learning enable examining brain architecture and its alterations beyond the conventional anatomical reference frame. In turn, allows researchers to gain deeper insights into the dynamics of concussions, treatment responses, and recovery processes. To guarantee that female athletes receive the optimal care they deserve, researchers must employ advanced neuroimaging techniques and sophisticated machine-learning models. These tools enable an in-depth investigation of the underlying mechanisms responsible for concussion symptoms stemming from neuronal dysfunction in female athletes. This paper endeavors to address the crucial issue of sex differences in multimodal neuroimaging experimental design and machine learning approaches within female athlete populations, ultimately ensuring that they receive the tailored care they require when facing the challenges of concussions

Authors: Fu, CHY; Erus, G; Fan, Y; Antoniades, M; Arnone, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: BMC Psychiatry
• Volume: 23
• Issue: 1
• Pages: 59-59
• Article number: 59
• Publication date: 2023-01-23
• DOI: 10.1186/s12888-022-04509-7
• EISSN: 1471-244X
• ISSN: 1471-244X
• Language: English
• Keywords: Function (biology); Psychology; Major depressive disorder; Neuroscience; Psychiatry; Neuroimaging; Biology; Cognition; Brain function; Brain Structure and Function; Medicine