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Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

Abstract:

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5 antibody 1B7 that blocks LRP1-mediated internalization without affecting the aggrecanolytic activity. Addition of 1B7 to cultured human chondrocytes revealed the full aggrecanolytic activity of ADA...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/19420862.2017.1304341

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
McCafferty, J More by this author
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Grant:
20563; Center for Osteoarthritis Pathogenesis (20205);
Publisher:
Taylor and Francis Publisher's website
Journal:
mAbs Journal website
Volume:
9
Issue:
4
Pages:
595-602
Publication date:
2017-03-17
Acceptance date:
2017-03-05
DOI:
EISSN:
1942-0870
ISSN:
1942-0862
Pubs id:
pubs:686825
URN:
uri:fe0e3165-3193-4fdd-93a8-537794f3a543
UUID:
uuid:fe0e3165-3193-4fdd-93a8-537794f3a543
Local pid:
pubs:686825

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