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Journal article

Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes.

Abstract:

The recently identified TMEM16/anoctamin protein family includes Ca(2+)-activated anion channels (TMEM16A, TMEM16B), a cation channel (TMEM16F) and proteins with unclear function. TMEM16 channels consist of eight putative transmembrane domains (TMs) with TM5-TM6 flanking a re-entrant loop thought to form the pore. In TMEM16A this region has also been suggested to contain residues involved in Ca(2+) binding. The role of the putative pore-loop of TMEM16 channels was investigated using a chimeri...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Journal of physiology More from this journal
Volume:
591
Issue:
Pt 14
Pages:
3487-3505
Publication date:
2013-07-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Language:
English
Keywords:
Pubs id:
pubs:406709
UUID:
uuid:fe00454b-6ce9-4a17-a2d7-41cfa244b2c1
Local pid:
pubs:406709
Source identifiers:
406709
Deposit date:
2013-11-16

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