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Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.

Abstract:

Malaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona alkaloids; this reduction is proportional to the disease severity. There is increased plasma protein binding, predominantly to alpha 1-acid glycoprotein, and elimination half-lives (in healthy adults quinine t1/2z = 11 hours, quinidine t1/2z = 8 hours) are prolonged by 50%. Systemic clearance is predominantly by hepatic biotransformation to more polar metabolites (quinine 80%, ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Clinical pharmacokinetics More from this journal
Volume:
30
Issue:
4
Pages:
263-299
Publication date:
1996-04-01
DOI:
ISSN:
0312-5963
Language:
English
Keywords:
Pubs id:
pubs:45161
UUID:
uuid:fdfc8e05-fb16-4028-bbec-f9c518fa8db7
Local pid:
pubs:45161
Source identifiers:
45161
Deposit date:
2012-12-19

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