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Journal article

No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.

Abstract:

The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patients. The coding region of this beta-cell type channel gene was investigated in 192 diabetics with a family history of the disorder by single-stranded conformational polymorphism (SSCP) analysis. Two s...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1995.1915

Authors


Iwamoto, K More by this author
Shimokawa, K More by this author
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Journal:
Biochemical and biophysical research communications
Volume:
211
Issue:
3
Pages:
1036-1040
Publication date:
1995-06-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:fdf9d62a-2aad-4431-a6bd-f64f04a7484e
Source identifiers:
115250
Local pid:
pubs:115250

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