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Journal article

Viral load, clinical disease severity and cellular immune responses in primary varicella zoster virus infection in Sri Lanka.

Abstract:

BACKGROUND: In Sri Lanka, varicella zoster virus (VZV) is typically acquired during adulthood with significant associated disease morbidity and mortality. T cells are believed to be important in the control of VZV replication and in the prevention of reactivation. The relationship between viral load, disease severity and cellular immune responses in primary VZV infection has not been well studied. METHODOLOGY: We used IFNgamma ELISpot assays and MHC class II tetramers based on VZV gE and IE63...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0003789

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Role:
Author
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NIHR Biomedical Research Centre Programme More from this funder
Medical Research Council More from this funder
Commonwealth Commission More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
3
Issue:
11
Pages:
e3789
Publication date:
2008-01-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:fde5a64c-457c-4b6e-9c48-2ad2e7829aa6
Source identifiers:
15821
Local pid:
pubs:15821

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