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Journal article

Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis.

Abstract:

Previous imaging studies have suggested that there is substantial axonal loss in the normal-appearing white matter (NAWM) of brains from multiple sclerosis patients and that this axonal loss may be an important determinant of disability. Recently, substantial axonal loss in the NAWM has been confirmed directly in post-mortem tissue. Whether the NAWM changes occur as a consequence of damage to axons traversing lesions or to a more diffuse injury process is uncertain. Using formalin-fixed brain...

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Publication status:
Published

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Publisher copy:
10.1093/brain/123.9.1845

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
123 ( Pt 9)
Issue:
9
Pages:
1845-1849
Publication date:
2000-09-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:fddc7086-56a8-44a0-93a9-e153a38aa8e7
Source identifiers:
116386
Local pid:
pubs:116386

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