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Multiscale analysis of T cell activation: Correlating in vitro and in vivo analysis of the immunological synapse

Abstract:

Recently implemented fluorescence imaging techniques, such as total internal reflection fluorescence microscopy and two-photon laser scanning micro-scopy, have made possible multiscale analysis of the immune response from single molecules in an interface to cells moving in lymphoid tissues and tumors. In this review, we consider components of T cell sensitivity: the immunological synapse, the coordination of migration, and antigen recognition in vivo. Potency, dose, and detection threshold fo...

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Publisher copy:
10.1007/978-3-540-93864-4-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Current Topics in Microbiology and Immunology More from this journal
Volume:
334
Issue:
1
Pages:
47-70
Publication date:
2009-01-01
DOI:
ISSN:
0070-217X
Language:
English
Pubs id:
pubs:426328
UUID:
uuid:fdd3e2ee-6f5f-465b-8fda-c713a3aac8e4
Local pid:
pubs:426328
Source identifiers:
426328
Deposit date:
2014-07-10

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