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Heregulin-induced epigenetic regulation of the utrophin-A promoter.

Abstract:

Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed he...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
FEBS letters More from this journal
Volume:
581
Issue:
22
Pages:
4153-4158
Publication date:
2007-09-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:429220
UUID:
uuid:fdce1115-f765-4cbd-bbe5-09ccfda9eb8e
Local pid:
pubs:429220
Source identifiers:
429220
Deposit date:
2013-11-16

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