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Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses

Abstract:

Vaccine development to prevent Salmonella Typhi infections has accelerated over the past decade, resulting in licensure of new vaccines, which use the Vi polysaccharide (Vi PS) of the bacterium conjugated to an unrelated carrier protein as the active component. Antibodies elicited by these vaccines are important for mediating protection against typhoid fever. However, the characteristics of protective and functional Vi antibodies are unknown. In this study, we investigated the human antibody ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciimmunol.abj1181

Authors


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Role:
Author
ORCID:
0000-0003-2844-6066
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-2576-8783
Publisher:
American Association for the Advancement of Science
Journal:
Science Immunology More from this journal
Volume:
6
Issue:
64
Article number:
eabj1181
Publication date:
2021-10-29
Acceptance date:
2021-09-27
DOI:
EISSN:
2470-9468
Language:
English
Keywords:
Pubs id:
1207615
Local pid:
pubs:1207615
Deposit date:
2021-11-17

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