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Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study

Abstract:

Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic assays screen only common resistance-determining mutations. We used whole-genome sequencing to characterise common and rare mutations predicting drug resistance, or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis.Between Sept 1, 2010, and Dec 1, 2013, we sequenced a training set of 2...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1473-3099(15)00062-6

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Elsevier
Journal:
Lancet. Infectious diseases More from this journal
Volume:
15
Issue:
10
Pages:
1193-1202
Publication date:
2015-10-01
DOI:
ISSN:
1473-3099
Pmid:
26116186
Language:
English
Keywords:
Pubs id:
pubs:567681
UUID:
uuid:fd2d50ea-9799-4daa-9eac-c9e7731f7957
Local pid:
pubs:528545
Source identifiers:
567681
Deposit date:
2017-01-03

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