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Genetic mouse models relevant to schizophrenia: taking stock and looking forward.

Abstract:

Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Neuropharmacology More from this journal
Volume:
62
Issue:
3
Pages:
1164-1167
Publication date:
2012-03-01
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
Language:
English
Keywords:
Pubs id:
pubs:179564
UUID:
uuid:fd2c7fba-6065-4a7d-a839-290df0eaea84
Local pid:
pubs:179564
Source identifiers:
179564
Deposit date:
2012-12-19

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