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Genetic mouse models relevant to schizophrenia: taking stock and looking forward.

Abstract:

Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Pritchett, D More by this author
Stumpenhorst, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Neuropharmacology
Volume:
62
Issue:
3
Pages:
1164-1167
Publication date:
2012-03-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:fd2c7fba-6065-4a7d-a839-290df0eaea84
Source identifiers:
179564
Local pid:
pubs:179564

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