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“I’d go on a hike with my kids… that would make me feel so happy.” Recognising what people with haemophilia B identify as meaningful when considering personal goals and the potential for gene therapy

Abstract:

Introduction: Historically people with haemophilia B (PwHB) have experienced adverse clinical outcomes including joint bleeds, pain and arthropathy. The current management of severe and moderate haemophilia B in the UK is largely through the use of factor replacement therapy often given as prophylaxis. Despite this, research reveals reduced quality of life (QoL) and psychological burden in PwHB of all severities, highlighting unmet need. Contemporary therapeutic developments including extende...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.2478/jhp-2025-0001

Authors

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Role:
Author
ORCID:
0000-0003-2001-5958
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Role:
Author
ORCID:
0000-0001-7809-499X
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-9018-6176
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Role:
Author
ORCID:
0000-0002-2704-0606


Publisher:
Paradigm Publishing
Journal:
The Journal of Haemophilia Practice More from this journal
Volume:
12
Issue:
1
Pages:
1-14
Publication date:
2025-03-19
DOI:
EISSN:
2055-3390
ISSN:
2055-3390


Language:
English
Keywords:
Pubs id:
2301411
Local pid:
pubs:2301411
Source identifiers:
2785108
Deposit date:
2025-03-20
ARK identifier:
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