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Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo

Abstract:

Ex vivo expansion of hematopoietic stem cells (HSCs) is one of the most promising strategies to increase the availability of transplantable HSCs and improve bone marrow transplantation outcomes. We recently demonstrated that mouse HSCs could be efficiently expanded in polyvinyl alcohol (PVA)-containing culture medium using only recombinant stem cell factor and thrombopoietin cytokines. However, the behavior of human HSCs in these simple PVA-based media was not fully elucidated. In this study,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.scr.2021.102531

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
ORCID:
0000-0001-7406-0151
More from this funder
Name:
Kay Kendall Leukaemia Fund
Grant:
KKL1378
More from this funder
Name:
Leukemia and Lymphoma Society
Publisher:
Elsevier
Journal:
Stem Cell Research More from this journal
Volume:
56
Article number:
102531
Publication date:
2021-09-03
Acceptance date:
2021-09-01
DOI:
ISSN:
1873-5061
Language:
English
Keywords:
Pubs id:
1193885
Local pid:
pubs:1193885
Deposit date:
2021-09-04

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