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Journal article

Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.

Abstract:

BACKGROUND: Faecal urgency and incontinence with rectal hypersensitivity is a distressing, unexplained disorder that is inadequately treated. We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities. METHODS: We compared full-thickness rectal biopsy samples from nine patients with physiologically characterised rectal hypersensitivity with...

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Publication status:
Published

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Journal:
Lancet
Volume:
361
Issue:
9355
Pages:
385-391
Publication date:
2003-02-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:fd02b0ef-cf13-4583-9b4c-11d837554caa
Source identifiers:
32309
Local pid:
pubs:32309

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