- Abstract:
-
BACKGROUND: Faecal urgency and incontinence with rectal hypersensitivity is a distressing, unexplained disorder that is inadequately treated. We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities. METHODS: We compared full-thickness rectal biopsy samples from nine patients with physiologically characterised rectal hypersensitivity with...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(03)12392-6
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- Journal:
- Lancet
- Volume:
- 361
- Issue:
- 9355
- Pages:
- 385-391
- Publication date:
- 2003-02-05
- DOI:
- EISSN:
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1474-547X
- ISSN:
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0140-6736
- URN:
-
uuid:fd02b0ef-cf13-4583-9b4c-11d837554caa
- Source identifiers:
-
32309
- Local pid:
- pubs:32309
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.
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