Surgical resection versus biopsy in the treatment of primary central nervous system lymphoma: a systematic review and meta-analysis

Journal article

Primary lymphoma of the central nervous system (PCNSL) is a rare and aggressive form of extranodal non-Hodgkin lymphoma primarily involving the brain, spinal cord, cerebrospinal fluid, and eyes. The role of surgical intervention in PCNSL is currently limited to biopsy and decompression of critical structures if needed – extended resection is debated. Chemotherapy is the mainstay of treatment. In lower and middle-income countries (LMICs), issues like delayed diagnosis and resource constraints are widespread. These guidelines provide a framework for addressing PCNSL in LMICs, emphasizing the importance of early diagnosis, tailored treatment approaches, and ongoing patient monitoring to improve outcomes for this rare and aggressive disease. Keywords: Lymphoma, non-Hodgkin, biopsy, nervous system, physiologic decompression, spinal cord, brain tumour

Authors: Chojak, R; Koźba-Gosztyła, M; Polańska, K; Rojek, M; Chojko, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Journal of Neuro-Oncology
• Volume: 160
• Issue: 3
• Pages: 753-761
• Publication date: 2022-11-30
• DOI: 10.1007/s11060-022-04200-7
• EISSN: 1573-7373
• ISSN: 0167-594X
• Language: English
• Keywords: Hazard ratio; Medicine; Chemotherapy; Odds ratio; Radiation therapy; Primary central nervous system lymphoma; Biopsy; Confidence interval; Internal medicine; Proportional hazards model; Lymphoma; Progression-free survival; Surgery