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Journal article

Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates.

Abstract:

Chloroquine (CQ) has been the mainstay of malaria treatment for more than 60 years. However, the emergence and spread of CQ resistance now restrict its use to only a few areas where malaria is endemic. The aim of the present study was to investigate whether a novel combination of a CQ-like moiety and an imipramine-like pharmacophore can reverse CQ resistance ex vivo. Between March to October 2011 and January to September 2013, two "reversed chloroquine" (RCQ) compounds (PL69 and PL106) were t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01048-15

Authors


Wirjanata, G More by this author
Sebayang, BF More by this author
Chalfein, F More by this author
Handayuni, I More by this author
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National Health and Medical Research Council of Australia More from this funder
Wellcome Trust More from this funder
Swiss National Science Foundation More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
59
Issue:
9
Pages:
5721-5726
Publication date:
2015
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:fcfe3919-5661-4987-ba24-6ebb774a67c7
Source identifiers:
531014
Local pid:
pubs:531014
Language:
English

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