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A general copper-mediated nucleophilic 18F fluorination of arenes

Abstract:

Molecules labeled with fluorine-18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [ 18F]F-. In the ideal case, the 18F fluorination of these substrates would be performed through reaction of [18F]KF with shelf-stable readily available precursors using a broadly applicable method suitable for automation. Herein, we describe the realization of these requirements with the p...

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Publisher copy:
10.1002/anie.201404436

Authors


Tredwell, M More by this author
Preshlock, SM More by this author
Taylor, NJ More by this author
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Journal:
Angewandte Chemie - International Edition
Volume:
53
Issue:
30
Pages:
7751-7755
Publication date:
2014-07-21
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:fced02e8-1335-4d3e-81e6-e9bbfb906b0f
Source identifiers:
478252
Local pid:
pubs:478252

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