Journal article

Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria

Abstract:: In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data were evaluated using noncompartmental analysis. There were no clinically relevant differences in the pharmacokinetics of amodiaquine and desethylamodiaquine between pregnant (n = 24) and postpartum (n = 18) women. The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during pregnancy. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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APA Style

Rijken, M., Mcgready, R., Phyo, A., Win, A., Hsi, P., Nosten, F., Tarning, J., Lindegardh, N., White, N., Jullien, V., Cammas, M., & Singhasivanon, P. (2011). Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria. Antimicrobial Agents and Chemotherapy, 55(9), 4338–4342.

MLA Style

Rijken, M., et al. “Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium Vivax Malaria.” Antimicrobial Agents and Chemotherapy, vol. 55, no. 9, 2011, pp. 4338–42.

Chicago Style

Rijken, M, R Mcgready, A Phyo, A Win, P Hsi, F Nosten, J Tarning, et al. 2011. “Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium Vivax Malaria.” Antimicrobial Agents and Chemotherapy 55 (9): 4338–42.
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Publisher copy:: 10.1128/AAC.00154-11

Authors

+ Rijken, M More by this author

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+ Mcgready, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Role:: Author

+ Phyo, A More by this author

Role:: Author

+ Win, A More by this author

Role:: Author

+ Hsi, P More by this author

Role:: Author

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Journal:: Antimicrobial Agents and Chemotherapy More from this journal
Volume:: 55
Issue:: 9
Pages:: 4338-4342
Publication date:: 2011-09-01
DOI:: 10.1128/AAC.00154-11
EISSN:: 1098-6596
ISSN:: 0066-4804

Pubs id:: pubs:179445
UUID:: uuid:fcc975a9-e47f-416e-8167-e094f0bf5dd1
Local pid:: pubs:179445
Source identifiers:: 179445
Deposit date:: 2012-12-19

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Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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