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Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria

Abstract:

In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data...

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Publisher copy:
10.1128/AAC.00154-11

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Antimicrobial Agents and Chemotherapy
Volume:
55
Issue:
9
Pages:
4338-4342
Publication date:
2011-09-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:fcc975a9-e47f-416e-8167-e094f0bf5dd1
Source identifiers:
179445
Local pid:
pubs:179445

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