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Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies.

Abstract:

Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Biozzi AB/H (H-2dq1) mice by active sensitization with spinal cord antigens. A single i.p. injection of CD8-depleting (YTS169.4) monoclonal antibody (mAb) failed to affect the clinical course of CREAE when administered prior to and during the onset of both the initial clinical and subsequent relapse phase of the disease. By contrast similar treatment with both CD4-depleting (YTS191.1) or CD4-blocking/non-depletin...

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Publication status:
Published

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Journal:
Journal of neuroimmunology More from this journal
Volume:
45
Issue:
1-2
Pages:
1-14
Publication date:
1993-06-01
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
Language:
English
Keywords:
Pubs id:
pubs:27298
UUID:
uuid:fcc88fe5-ebaf-4e78-84f8-b64cc58d54d4
Local pid:
pubs:27298
Source identifiers:
27298
Deposit date:
2012-12-19

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