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Journal article

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of mouse brain

Abstract:

Aging is the biggest risk factor for Parkinson’s disease (PD). The majority of PD cases are non-familial, and the connection between aging and PD-associated genes is not well understood. Haploinsufficiency in GBA, leading to a reduction in glucocerebrosidase (GCase) activity, is one of the most common genetic risk factors for PD. Furthermore, GCase activity is also reduced in brain regions of sporadic PD patients, with a corresponding accumulation of its glycosphingolipid (GSL) substrates. Re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neurobiolaging.2018.02.028

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Platt, FM
Grant:
Investigator in Science
More from this funder
Name:
Royal Society
Funding agency for:
Platt, FM
Grant:
Investigator in Science
More from this funder
Name:
Parkinson’s UK
Funding agency for:
Huebecker, M
Grant:
1501
More from this funder
Name:
National Institutes of Health
Grant:
NIH /NINDS 1R01NS092667-01
Publisher:
Elsevier
Journal:
Neurobiology of Aging More from this journal
Volume:
67
Pages:
189-200
Publication date:
2018-03-29
Acceptance date:
2018-02-25
DOI:
ISSN:
0197-4580
Keywords:
Pubs id:
pubs:826677
UUID:
uuid:fcad48ea-64ef-40f1-ab0d-7ba8437b6e9b
Local pid:
pubs:826677
Source identifiers:
826677
Deposit date:
2018-02-26

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