Journal article icon

Journal article

The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection.

Abstract:

Bacterial transcription is initiated after RNA polymerase (RNAP) binds to promoter DNA, melts ~14 bp around the transcription start site and forms a single-stranded "transcription bubble" within a catalytically active RNAP-DNA open complex (RP(o)). There is significant flexibility in the transcription start site, which causes variable spacing between the promoter elements and the start site; this in turn causes differences in the length and sequence at the 5' end of RNA transcripts and can be...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2012.12.015

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Expand authors...
Journal:
Journal of molecular biology
Volume:
425
Issue:
5
Pages:
875-885
Publication date:
2013-03-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:fca62304-2ddc-4c6f-8e53-6c54074467a7
Source identifiers:
369828
Local pid:
pubs:369828

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP