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Transfer of 4'-chloro-2,2':6',2"-terpyridine platinum(II) between human serum albumin, glutathione and other thiolate ligands. A possible selective natural transport mechanism for the delivery of platinum(II) drugs to tumour cells.

Abstract:

The antitrypanosomal and antitumour activities of (2,2':6',2"-terpyridine)platinum(II) complexes have been postulated to be due to their ability to inhibit irreversibly the NADPH/FAD redox enzymes trypanothione reductase and human thioredoxin reductase respectively. Here we show that these platinum(II) complexes metallate recombinant human albumin (rHA) at the single free thiol group (Cys-34). Moreover, the (2,2':6',2"-terpyridine)platinum(II) complex can be transferred from rHA to other thio...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Anti-cancer drug design More from this journal
Volume:
15
Issue:
6
Pages:
431-439
Publication date:
2000-12-01
EISSN:
1460-2148
ISSN:
0266-9536
Language:
English
Keywords:
Pubs id:
pubs:264071
UUID:
uuid:fca31b3b-26d9-41a7-895c-1327b81b3af0
Local pid:
pubs:264071
Source identifiers:
264071
Deposit date:
2013-11-17

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