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Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Abstract:

Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HLA-B27 heavy chains aberrantly form homodimers, is a central hypothesis that attempts to explain the role of HLA-B27 in disease pathogenesis. Here, we examined the ability of the eight most prevalen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra119.010257

Authors


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Role:
Author
ORCID:
0000-0001-7038-1214
More by this author
Role:
Author
ORCID:
0000-0002-3502-9351
More by this author
Role:
Author
ORCID:
0000-0002-9739-6157
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of Biological Chemistry More from this journal
Volume:
294
Issue:
52
Pages:
20185-20195
Publication date:
2019-11-18
Acceptance date:
2019-11-18
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
31740583

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