Journal article
Tetramate derivatives by chemoselective Dieckmann ring closure of<i>allo</i>-phenylserines, and their antibacterial activity
- Abstract:
- -phenylserine systems, showing the importance of steric bulk around the bicyclic ring system. The derived C7-carboxamidotetramates, but not C7-acyl systems, exhibited potent antibacterial activity against MRSA, with the most active compounds exhibiting well-defined physicochemical and structure-activity properties. This work clearly demonstrates that densely functionalised tetramates are both readily available and may exhibit high levels of antibacterial activity.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1039/d3ob00376k
Authors
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- 10.13039/501100000266
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic & Biomolecular Chemistry More from this journal
- Volume:
- 21
- Issue:
- 19
- Pages:
- 4061-4071
- Publication date:
- 2023-05-17
- DOI:
- EISSN:
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1477-0539
- ISSN:
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1477-0520
- Language:
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English
- Keywords:
- Pubs id:
-
1339734
- Local pid:
-
pubs:1339734
- Source identifiers:
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W4365802791
- Deposit date:
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2026-05-07
- ARK identifier:
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- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
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