Journal article
Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention
- Abstract:
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Abstract
In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop new antibiotics via downregulation of phenazine biosynthesis.Graphical abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 793.9KB, Terms of use)
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- Publisher copy:
- 10.1007/s00706-017-2100-z
Authors
- Publisher:
- Springer
- Journal:
- Monatshefte für Chemie - Chemical Monthly More from this journal
- Volume:
- 149
- Issue:
- 4
- Pages:
- 847-856
- Publication date:
- 2017-11-30
- DOI:
- EISSN:
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1434-4475
- ISSN:
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0026-9247
- Language:
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English
- Keywords:
- Pubs id:
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2359798
- Local pid:
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pubs:2359798
- Source identifiers:
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W2773523101
- Deposit date:
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2026-01-15
- ARK identifier:
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Terms of use
- Copyright date:
- 2017
- Licence:
- CC Attribution (CC BY)
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