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Shielding and activation of a viral membrane fusion protein.

Abstract:

Entry of enveloped viruses relies on insertion of hydrophobic residues of the viral fusion protein into the host cell membrane. However, the intermediate conformations during fusion remain unknown. Here, we address the fusion mechanism of Rift Valley fever virus. We determine the crystal structure of the Gn glycoprotein and fit it with the Gc fusion protein into cryo-electron microscopy reconstructions of the virion. Our analysis reveals how the Gn shields the hydrophobic fusion loops of the ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-02789-2

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-9353-0355
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Role:
Author
ORCID:
0000-0002-8066-8785
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
349
Publication date:
2018-01-05
Acceptance date:
2017-12-28
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:821518
URN:
uri:fc712bc3-1fec-4da7-a5a7-8a8e9758fcac
UUID:
uuid:fc712bc3-1fec-4da7-a5a7-8a8e9758fcac
Local pid:
pubs:821518
Language:
English
Keywords:

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