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Journal article

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

Abstract:

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2566

Authors


Bojesen, SE More by this author
Pooley, KA More by this author
Johnatty, SE More by this author
Beesley, J More by this author
Michailidou, K More by this author
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Journal:
Nature genetics
Volume:
45
Issue:
4
Pages:
371-384e2
Publication date:
2013-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:fc70f4e5-5d4a-403e-a995-f09b27449697
Source identifiers:
395515
Local pid:
pubs:395515

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