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Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse.

Abstract:

The slow Wallerian degeneration mouse (C57BL/Wld(s)) is a mutant strain of mouse, with the unique phenotype of prolonged survival of the distal axon following axotomy. The causative mutation is an 85 kb tandem triplication on distal mouse chromosome 4. The dominant slow Wallerian degeneration phenotype is conferred by a hybrid gene within the triplication, comprising a gene of previously unknown function, D4Cole1e, and the 5' end of ubiquitination factor E4B (Ube4b). It encodes an in-frame fu...

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Publication status:
Published

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Journal:
Gene More from this journal
Volume:
284
Issue:
1-2
Pages:
23-29
Publication date:
2002-02-01
DOI:
EISSN:
1879-0038
ISSN:
0378-1119

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