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Journal article

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.

Abstract:

The cell surface molecules CD4 and CD8 greatly enhance the sensitivity of T-cell antigen recognition, acting as "co-receptors" by binding to the same major histocompatibility complex (MHC) molecules as the T-cell receptor (TCR). Here we use surface plasmon resonance to study the binding of CD8alphaalpha to class I MHC molecules. CD8alphaalpha bound the classical MHC molecules HLA-A*0201, -A*1101, -B*3501, and -C*0702 with dissociation constants (K(d)) of 90-220 microm, a range of affinities d...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.275.20.15232

Authors


Willcox, BE More by this author
Boulter, JM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
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Journal:
The Journal of biological chemistry
Volume:
275
Issue:
20
Pages:
15232-15238
Publication date:
2000-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:fc620b28-0a2c-46d5-9f22-30d1a09de589
Source identifiers:
4842
Local pid:
pubs:4842

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