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A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.

Abstract:

A phosphine-free palladium catalyst for aqueous Suzuki-Miyaura cross-coupling is presented. The catalyst is active enough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and proteins. The Suzuki-Miyaura couplings on protein substrates are the first to proceed in useful conversions. Notably, hydrophobic aryl and vinyl groups can be transferred to the protein surface without the aid of organic solvent since the aryl- and vinylboronic acids used in the...

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Publication status:
Published

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Publisher copy:
10.1021/ja907150m

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Journal of the American Chemical Society
Volume:
131
Issue:
45
Pages:
16346-16347
Publication date:
2009-11-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:fc60dc4a-a8ad-42c3-ac2b-b5b49f86e71d
Source identifiers:
34948
Local pid:
pubs:34948

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