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The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.

Abstract:

Phosphorylase kinase (PhK) coordinates hormonal and neuronal signals to initiate the breakdown of glycogen. The enzyme catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation of active glycogen phosphorylase a. We present a 9.9 angstroms resolution structure of PhK heterotetramer (alphabetagammadelta)4 determined by cryo-electron microscopy single-particle reconstruction. The enzyme has a butterfly-like shape comprising two lobes with 222 symmetry....

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2008.10.013

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Journal:
Structure (London, England : 1993)
Volume:
17
Issue:
1
Pages:
117-127
Publication date:
2009-01-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:fc5e2b47-fd29-4e14-b2ff-9fa4ad5f6fe7
Source identifiers:
100245
Local pid:
pubs:100245

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