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Journal article

Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods

Abstract:

Introduction

Macaques play a central role in human tuberculosis(TB) vaccine development. Immune and challenge responses differ across macaque and human subpopulations. We determined which macaque subpopulations best predicted immune responses in different human subpopulations, using novel immunostimulation/immunodynamic modelling methods in a proof of concept study.

Methods

Data on IFN-γ secreting CD4+ T cells over time after recent BCG vaccination were a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/CVI.00525-16

Authors


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Name:
UNITAID
Grant:
PO 8477-0-600
More from this funder
Name:
Bill and Melinda Gates Foundation
Grant:
OPP1160830
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Name:
European Union
Grant:
MR/P002404/1
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Name:
Department for International Development
Grant:
MR/P002404/1
More from this funder
Name:
Medical Research Council
Grant:
MR/P002404/1
Publisher:
American Society of Microbiology
Journal:
Clinical and Vaccine Immunology More from this journal
Volume:
24
Issue:
3
Pages:
e00525-16
Publication date:
2017-01-01
Acceptance date:
2017-01-04
DOI:
ISSN:
1556-679X
Language:
English
Pubs id:
pubs:671511
UUID:
uuid:fc59b024-c55a-48e4-b864-1e7886644a44
Local pid:
pubs:671511
Source identifiers:
671511
Deposit date:
2017-02-01

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